Psoriasis and Heart Disease

Psoriasis and Cardiovascular Risk: Understanding the Link and Prevention Strategies

As a seasoned Rheumatologist, I understand the concerns and challenges faced by individuals with psoriasis and psoriatic arthritis. In particular when it comes to their increased risk of developing metabolic syndrome and cardiovascular disease. This blog post aims to shed light on the intricate connection between these conditions, emphasizing the importance of managing inflammation and adopting comprehensive strategies that include nutrition, supplements, and disease-modifying medications.

Understanding Psoriasis and Inflammation

Psoriasis is an autoimmune condition that affects the skin, causing red, scaly patches. Recent research has revealed that psoriasis is more than just a skin-deep concern. It is a systemic disorder associated with chronic inflammation. Inflammatory molecules, such as cytokines, are released, contributing to the development of a pro-inflammatory state within the body.


The Link with Metabolic Syndrome

Metabolic syndrome is a cluster of interconnected conditions, including obesity, high blood pressure, high blood sugar levels, and abnormal cholesterol levels. Studies have shown that individuals with psoriasis are more likely to develop metabolic syndrome than those without the condition. The underlying inflammation in psoriasis can disrupt the body’s metabolic processes, leading to insulin resistance, abnormal lipid profiles, and obesity.


Cardiovascular Disease: The Unwanted Companion

The connection between psoriasis, metabolic syndrome, and cardiovascular disease is not coincidental. Metabolic syndrome significantly increases the risk of developing cardiovascular diseases, such as coronary artery disease, heart attacks, and strokes. The chronic inflammation in psoriasis, coupled with the metabolic abnormalities, can accelerate the progression of atherosclerosis, the buildup of plaque in the arteries.


Controlling Inflammation

Managing inflammation is a key strategy to mitigate the risk of metabolic syndrome and subsequent cardiovascular disease in individuals with psoriasis/psoriatic arthritis. Various approaches can be employed to achieve this, and here are some effective strategies:


Adopting an anti-inflammatory diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can help reduce inflammation and promote overall well-being. Omega-3 fatty acids, found in fish oil, have demonstrated anti-inflammatory properties and may be beneficial.


Certain supplements, such as vitamin D, have shown promise in managing psoriasis and reducing inflammation. However, it is essential to consult with a healthcare professional before starting any supplement regimen.

Disease-modifying medication

In some cases, disease-modifying medications, such as biologic agents, can be prescribed to target the underlying inflammatory processes in psoriasis/psoriatic arthritis. These medications have been shown to improve symptoms and potentially reduce the risk of associated metabolic and cardiovascular complications.


The importance of prevention

By controlling inflammation and managing metabolic syndrome, individuals with psoriasis/psoriatic arthritis can significantly reduce their risk of developing cardiovascular disease. Early detection, regular check-ups, and working closely with healthcare professionals, such as rheumatologists and dermatologists, are vital for preventing or managing these interconnected conditions.



Psoriasis and psoriatic arthritis are more than just skin conditions; they can significantly impact an individual’s overall health, particularly in relation to metabolic syndrome and cardiovascular disease. By understanding the underlying mechanisms and implementing comprehensive strategies that control inflammation through nutrition, supplements, and disease-modifying medications, individuals can take proactive steps to reduce their risk and safeguard their cardiovascular health. Remember, early intervention and collaboration with healthcare professionals are crucial for optimal outcomes.


Relevant Medical Literature

  1. Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies. J Am Acad Dermatol. 2013; 68(4): 654-662.
  2. Mehta NN, Yu Y, Saboury B, et al. Systemic and Vascular Inflammation in Patients with Moderate to Severe Psoriasis as measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG-PET/CT): A Pilot Study. Arch Dermatol. 2011; 147(9): 1031-1039.
  3. Gelfand JM, Neimann AL, Shin DB, et al. Risk of Myocardial Infarction in Patients with Psoriasis. JAMA. 2006; 296(14): 1735-1741.


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