Are you struggling to lose weight despite trying numerous diets and exercise plans? Peptides might be the solution you’re looking for. These small proteins target metabolism, hunger, and fat loss, offering new hope for those who need extra support on their weight loss journey.

At Chicago Arthritis and Regenerative Medicine, Dr. Siddharth Tambar explains how different peptides work, which are FDA-approved, and how they can be integrated into your weight loss plan.

GLP-1 Agonists: Reducing Appetite and Controlling Blood Sugar

GLP-1 (glucagon-like peptide-1) agonists are a popular class of peptides for weight loss. They reduce appetite, improve blood sugar control, and enhance metabolic health. Two common GLP-1 agonists are:

1. Semaglutide – Sold under the brand names Wegovy and Ozempic, semaglutide is FDA-approved for weight loss and diabetes management. It works by mimicking the GLP-1 hormone to reduce hunger and control blood sugar levels.
2. Tirzepatide – Known by the brand names Mounjaro and Zepbound, tirzepatide is FDA-approved for type 2 diabetes and used off-label for weight loss. Unlike semaglutide, tirzepatide targets both GLP-1 and GIP (gastric inhibitory polypeptide) receptors, enhancing fat metabolism and insulin sensitivity.

A newer peptide, Retatrutide, is a triple receptor agonist in development. It targets GLP-1, GIP, and glucagon receptors, showing promising results for weight loss, blood sugar control, and overall metabolic health.

Growth Hormone Releasing Peptides (GHRPs)

Growth hormone releasing peptides (GHRPs) stimulate the release of growth hormone, supporting metabolism, fat loss, and muscle maintenance. Common GHRPs include:

• CJC-1295 – A long-acting peptide that boosts growth hormone levels over time, aiding in fat loss and muscle gain.
• Ipamorelin – Known for its minimal side effects, Ipamorelin works well when combined with CJC-1295 to maximize results without increasing hunger.
• Sermorelin – Often used to support growth hormone levels in aging adults or those with deficiencies.

These peptides are particularly effective for individuals who exercise regularly and want to maintain muscle mass while losing fat.

Fat-Targeting Peptides: AOD-9604 and Tesamorelin

Some peptides specifically target fat metabolism:

1. AOD-9604 – A fragment of human growth hormone designed to burn fat without affecting blood sugar levels. Though not FDA-approved for weight loss, it is used off-label to reduce stubborn fat.
2. Tesamorelin – FDA-approved for HIV-associated lipodystrophy, it’s used off-label to reduce abdominal fat and improve metabolic health.

Combining Peptides for Enhanced Results

One of the advantages of peptide therapy is the ability to combine peptides to enhance their effects. For example:

• CJC-1295 + Ipamorelin – This combination boosts growth hormone release, supporting both fat loss and muscle gain.
• GLP-1 Agonists + AOD-9604 – Helps reduce appetite while enhancing fat burning for significant weight loss.

Safety and Personalized Plans

While many peptides are used off-label, working with a knowledgeable physician is essential. Dr. Tambar emphasizes the importance of personalized treatment plans and regular follow-ups to monitor for potential side effects like nausea, headaches, and fluid retention.

The Bottom Line

Peptide therapy offers a powerful tool for weight loss, appetite control, and metabolic health. Whether you’re looking to lose fat, build muscle, or manage cravings, peptides can help — when combined with a healthy diet, exercise, and a personalized medical plan.

For more information, visit Chicago Arthritis and Regenerative Medicine and explore how peptide therapy can support your health goals.

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