If you’re dealing with knee arthritis and considering platelet-rich plasma (PRP) treatment, one of the most common questions is: how many treatments do I actually need? You’ve likely heard different opinions—some recommending three weekly injections, others suggesting just one. So what does the science really say?

Dr. Siddharth Tambar of Chicago Arthritis and Regenerative Medicine breaks it down clearly: the number of PRP treatments you need depends on the quality and concentration of the PRP being used.

What Is PRP and How Does It Work?

PRP, or platelet-rich plasma, is derived from your own blood. It’s processed to concentrate the platelets—cells that release growth factors promoting healing and reducing inflammation. When injected into the knee joint, PRP helps improve joint health, calms chronic inflammation, and strengthens surrounding soft tissue for better function and stability.

The Importance of PRP Concentration

Not all PRP is created equal. Many clinics offering three weekly injections are typically using low-dose PRP—lower in platelet concentration. The idea is that multiple low-dose injections may build up effectiveness over time. However, recent research shows that a single high-dose PRP injection is more effective, particularly for moderate knee arthritis.

We use high-concentration PRP in his clinic, designed for stronger, longer-lasting results with fewer treatments.

Recommended PRP Protocol

Here’s what we generally recommends:

Start with one high-dose PRP injection
Monitor progress over 3 to 6 months
Expect gradual improvement starting around one month
Peak benefits usually occur between 3 to 6 months

If you’re still progressing, no additional treatment is needed. If results plateau and you’re not yet at your goal, a second treatment may be discussed.

How Long Does Relief Last?

For moderate knee osteoarthritis, most patients benefit from one to two PRP treatments per year. The relief can last anywhere from two to three years, depending on the individual’s condition and lifestyle factors.

Severe arthritis may require earlier retreatment or stronger options like bone marrow stem cell therapy. Milder cases might need only one injection for extended relief.

Common Misconceptions About PRP

PRP is not the same as a steroid injection. Steroids may offer short-term relief but can damage cartilage over time. PRP supports healing without tissue damage.
You do not need three injections if you’re using high-quality PRP. One high-dose injection is usually enough to start.
Lack of improvement in the first week doesn’t mean PRP failed. With high-dose PRP, results take time—expect improvements to unfold gradually over several months.

Personalized Care Matters

Every patient is different. Treatment recommendations are based on arthritis severity, activity level, symptom history, and goals. PRP is not one-size-fits-all, and success relies heavily on the physician’s expertise and the technique used.

For best results, PRP should be combined with:

Physical therapy and strength training
Weight loss if needed
Anti-inflammatory nutrition
Supplements like omega-3s or turmeric

Lastly, be cautious of providers offering only low-dose PRP or those not addressing surrounding soft tissue. An expert physician should be treating the whole joint structure for optimal results.

Conclusion

You don’t need three weekly PRP injections—not if you’re using a high-quality, high-concentration PRP. One injection can lead to results lasting months, even years. Most patients with moderate knee arthritis benefit from just one or two treatments annually.

For expert, personalized care in PRP and non-surgical arthritis treatment, consult a regenerative medicine specialist who truly understands the science and practice.

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