A recent study from the UK explored the use of methotrexate, an immunosuppressant medication, in treating wear and tear knee osteoarthritis. The study involved over 200 patients from various clinics, divided into two groups: one receiving methotrexate and the other a placebo. This double-blind, placebo-controlled study ensured that neither the physicians nor the patients knew which treatment was administered.

After six months, researchers assessed improvements in knee pain, stiffness, and function. The methotrexate group experienced modest but significant symptom improvement compared to the placebo group, which showed no improvement. This finding challenges the traditional view that methotrexate is ineffective for wear and tear arthritis, typically thought to be distinct from autoimmune arthritis.

Rheumatologists often differentiate between wear and tear arthritis, resulting from joint instability and ligament weakness, and autoimmune arthritis, where the immune system causes widespread inflammation and joint damage. Methotrexate is commonly used for autoimmune arthritis, such as rheumatoid or psoriatic arthritis, but this study suggests it may have potential for wear and tear arthritis due to underlying inflammation.

Exploring Other Treatment Options

While methotrexate shows promise, it may be overkill for wear and tear arthritis due to potential side effects. Traditional treatments like anti-inflammatory medications and steroid injections provide short-term relief but have long-term risks. Therefore, exploring safer alternatives is essential.

1. Supplements: Over-the-counter supplements like omega-3, glucosamine, and turmeric can help reduce pain and inflammation in osteoarthritis.
2. Metabolic Health: Maintaining a low-inflammatory diet and addressing metabolic health can reduce inflammation and pain associated with wear and tear arthritis.
3. Regenerative Medicine: Treatments such as prolotherapy and PRP (Platelet-Rich Plasma) strengthen ligaments and address joint inflammation. Other options include alpha-2 macroglobulin and interleukin receptor antagonist protein, derived from the patient’s blood or bone marrow, offering anti-inflammatory benefits.

Conclusion

While methotrexate shows potential for osteoarthritis treatment, exploring safer and lower-risk options is advisable before considering this medication. Supplements, dietary changes, and regenerative medicine treatments may offer effective relief without the side effects associated with methotrexate.